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You do not need to pruneYou do not need to prune watermelon vines. If you want to try and grow an extra-large melon for a competition, you could cut off the lateral vines (as the best fruit is often on the main fine), but there's really no need to prune watermelon vines. You could also pinch off some of the blossoms to focus energy on less fruit.

2015 Special Edition Garden GuideCooking Fresh with The Old Farmer's AlmanacThe Almanac Monthly Digital MagazineWhat the heck is a Garden Hod?