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It is natural for vines toIt is natural for vines to wilt towards the end of the season and when the pumpkins are close to mature. If you still have green pumpkins on the vines you should check for insects. Squash bugs or borers can cause a lot of damage. Hand pick if possible or use an insecticidal soap or neem oil. If you have white spots on the leaves it could be a form of powdery mildew.

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